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Precautions and Warnings With Megestrol ES

There are a number of safety precautions that should be followed while using megestrol ES, as well as warnings of potentially dangerous complications. Tell your healthcare provider if you have a history of a blood clot or stroke before starting treatment with megestrol ES. It is also important for him or her to know about all other medications you are taking.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking megestrol ES (Megace® ES) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Megestrol ES Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • There have been reports of blood clots occurring in people taking megestrol ES. If you have had a blood clot in the past, talk to your healthcare provider about this possible side effect before taking megestrol ES or any megestrol product.
  • Megestrol ES may cause diabetes when used for extended periods, or worsen diabetes in people who already have the condition. If you have diabetes, your healthcare provider may recommend you check your blood sugar levels more closely while taking this medication.
  • Megestrol ES is approved to treat unexplained weight loss. Your healthcare provider will check for and treat any medical reasons for your weight loss, such as an infection, certain cancers, or problems absorbing nutrients, before starting treatment with megestrol ES.
  • There have been reports of people developing a condition known as Cushing's syndrome after taking this medication for extended periods. Tell your healthcare provider if you develop signs of Cushing's syndrome, such as:
    • Weight gain in your midsection or upper back
    • A rounder face than usual
    • Weakness
    • Tiredness
    • High blood pressure
    • Unexplained bruising.
  • People who take megestrol ES for extended periods may develop adrenal insufficiency (when the adrenal glands do not produce enough hormones) during treatment, or while stopping treatment. Adrenal insufficiency can make it harder for you to respond to stress, such as injury, illness, or surgery. Let your healthcare provider know if you become ill, plan to have surgery, or develop signs of adrenal insufficiency, such as:
  • It is not known whether megestrol ES has effects on viral replication of human immunodeficiency virus (HIV).
  • Megestrol ES is a pregnancy Category X medication, which means it should not be used by pregnant women (see Megace ES and Pregnancy).
  • Megestrol ES passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Megace ES and Breastfeeding).

Megestrol ES Medication Information

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