Drugs Home > Tolvaptan

Tolvaptan is taken once daily to help increase low blood sodium levels caused by things such as liver disease or heart failure. Your dosage is calculated based on how you respond to the medicine and other medications you are taking, among other factors. Although most people tolerate the drug well, side effects are possible and include a dry mouth, thirst, and weakness.

What Is Tolvaptan?

Tolvaptan (Samsca®) is a prescription medication approved to increase low blood sodium levels (known medically as hyponatremia) in people with certain medical conditions, including heart failure, liver disease, or syndrome of inappropriate antidiuretic hormone (SIADH). It should only be used in people who do not require urgent treatment to increase their sodium levels.
(Click What Is Tolvaptan Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, tolvaptan can cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common tolvaptan side effects include but are not limited to:
(Click Tolvaptan Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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