Drugs Home > Tapazole Warnings and Precautions

Tapazole, a prescription antithyroid medication, can cause severe liver damage, low white blood cell counts, and low blood platelets in certain people. In addition, alcohol should be avoided while taking it. Other warnings and precautions for Tapazole apply to women who are pregnant or breastfeeding and to people with certain allergies.

What Should I Tell My Healthcare Provider?

Prior to taking Tapazole® (methimazole), talk to your healthcare provider if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • A bleeding disorder
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medications, vitamins, and herbal supplements.

Specific Precautions and Warnings With Tapazole

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Tapazole can cause low blood cells, such as low white blood cells and low blood platelets. These conditions may be quite serious. Your healthcare provider should monitor your blood counts during treatment (usually using a simple blood test) to check for such problems. Let your healthcare provider know if you develop any signs of low blood cells, such as:
    • Easy bruising or bleeding.
  • This medication can cause serious liver reactions, which may result in death. Let your healthcare provider know right away if you develop signs of liver problems, such as:
    • Yellow eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Itching
    • Loss of appetite
    • Elevated liver enzymes (found using a blood test).
  • You should avoid alcohol while taking Tapazole, as additive effects (such as increased drowsiness, confusion, or memory loss) could occur.
  • Tapazole can potentially interact with other medications (see Tapazole Drug Interactions).
  • Tapazole is a pregnancy Category D medication, which means this drug presents clear risks to a fetus. Check with your healthcare provider before taking Tapazole when pregnant (see Methimazole and Pregnancy).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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