Drugs Home > Side Effects of Rabeprazole

The most common side effect of rabeprazole is a headache. However, it is important to note that not everyone who takes this medication will experience side effects. Side effects that are less common include constipation, infection, and sore throat. If you develop any side effects while taking this drug, or if something "just doesn't seem right," tell your healthcare provider.

Rabeprazole Side Effects: An Introduction

As with any medicine, there are possible side effects with rabeprazole (Aciphex®); but not everyone who takes rabeprazole will experience side effects. In fact, most people tolerate the medicine well. When people do develop side effects, in most cases they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(The side effects discussed below are not a complete list of side effects reported with rabeprazole. Your healthcare provider can discuss a more complete list of rabeprazole side effects with you.)

Common Rabeprazole Side Effects

Rabeprazole has been studied extensively in clinical trials, with over 1,000 people worldwide having been evaluated. In these studies, side effects are always documented.
Based on these studies, the most common side effects of rabeprazole included:
  • Headaches -- up to 9.9 percent of people
  • Diarrhea -- up to 4.5 percent
  • Nausea -- up to 4.5 percent
  • Vomiting -- up to 3.6 percent
  • Abdominal pain (stomach pain) -- up to 3.6 percent.
  • Pain (the type of pain was not specified) -- up to 3 percent
  • Sore throat -- up to 3 percent
  • Flatulence -- up to 3 percent
  • Infection -- up to 2 percent
  • Constipation -- up to 2 percent.
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Last reviewed by: Kristi Monson, PharmD;
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