Drugs Home > Precautions and Warnings of Rabeprazole

There are several rabeprazole precautions and warnings to be aware of. For example, this drug can interact with certain medications. Also, if you have severe liver disease, your healthcare provider may use caution when treating you with rabeprazole. Other rabeprazole precautions and warnings include talking to your doctor (prior to taking this drug) if you are pregnant or breastfeeding.

Rabeprazole: What Should I Tell My Healthcare Provider?

Prior to taking rabeprazole (Aciphex®), you should tell your healthcare provider if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Low blood magnesium (hypomagnesemia) 
  • Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Also, tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Some Precautions and Warnings of Rabeprazole

Some precautions and warnings to be aware of with rabeprazole include:
  • Studies indicate that people who take proton pump inhibitor medications (such as rabeprazole) may be at an increased risk for broken bones. The risk appears to be highest for people who take such medications at high doses or for long periods (over a year). You and your healthcare provider should take this into account when deciding if the benefits of this medication outweigh the risks for your particular situation.


  • The use of proton pump inhibitors (including this medication) may increase the risk of a potentially serious condition known as Clostridium difficile-associated diarrhea (CDAD). If you develop diarrhea that does not seem to improve (especially if it is watery and accompanied by a fever and abdominal pain), seek immediate medical attention. 


  • Rabeprazole can interact with certain medications (see Drug Interactions With Rabeprazole).
  • Rabeprazole is considered a pregnancy Category B medication, meaning that it is probably safe for use during pregnancy, although the full risks are currently unknown (see Aciphex and Pregnancy).
  • If you have severe liver disease, your healthcare provider may use caution when treating you with rabeprazole.


  • Proton pump inhibitors (PPIs), including rabeprazole, may cause low blood magnesium levels (hypomagnesemia). Seek immediate medical attention if you develop any symptoms of hypomagnesemia, such as muscle spasms, an irregular heart rhythm (arrhythmia), or seizures. Your healthcare provider may want to check your magnesium levels periodically using a simple blood test. 


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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