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Questran is commonly prescribed for the treatment of high cholesterol and itching caused by partial biliary obstruction. As a bile acid sequestrant, it works by binding to bile acids in the intestines, preventing them from being reabsorbed. Questran comes in powder form and should be mixed with liquids before consumed. Potential side effects include constipation, stomach discomfort, and gas.

What Is Questran?

Questran® (cholestyramine) is a prescription medication used to lower cholesterol levels in the body or to control itching associated with certain types of liver disease.

Who Makes It?

Questran is manufactured by Bristol-Myers Squibb for Par Pharmaceuticals.

What Is Questran Used For?

This medication has been licensed for several uses, including:
  • Lowering LDL cholesterol ("bad" cholesterol) in people with high total cholesterol
  • Relief of itching caused by a partial biliary obstruction.
(Click Questran Uses for more information on these specific uses, as well as possible off-label uses.)

How Does It Work?

Questran is part of a class of drugs known as bile acid sequestrants. It works by binding to bile acids in the intestines, preventing them from being reabsorbed back into the body. Bile acids are made in the liver from broken-down cholesterol. Therefore, removing these substances from your body helps to lower your blood cholesterol. The medication can lower both total and LDL cholesterol.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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