Drugs Home > Omeprazole Side Effects

Although most people tolerate omeprazole well, there are potential side effects of the medication. Some of the common side effects of omeprazole can include headaches, diarrhea, and dizziness. In many cases, side effects of the drug are minor and are easily treated. However, if you develop more serious side effects, such as depression or signs of an allergic reaction, you should notify your healthcare provider right away.

An Introduction to Omeprazole Side Effects

As with any medicine, side effects are possible with omeprazole (Prilosec®). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with omeprazole. Your healthcare provider can discuss a more complete list of omeprazole side effects with you.)

Serious Side Effects of Omeprazole

Some side effects of omeprazole, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:


    • Nausea
    • Fever or chills
    • Extreme pain in the upper abdomen
    • A rapid heartbeat (tachycardia) 


  • Signs of liver damage, such as yellowing in the whites of the eyes or skin, dark urine, or upper abdominal pain (or stomach pain)
  • Signs of an allergic reaction, including an unexplained rash, hives, itching, and unexplained swelling
  • Broken bones (some studies suggest this or other similar medications may increase the risk of bone fractures)
  • Signs of low blood magnesium (hypomagnesemia), such as:
    • Muscle spasm
    • An irregular heart rhythm (arrhythmia)
    • Seizures.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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