Drugs Home > Naltrexone Injection

Naltrexone injection is a medication prescribed for people who are trying to stop abusing alcohol and opioid medications. The injection is administered by a healthcare provider, who will administer the drug in the gluteal muscle (buttocks) once a month. Side effects are possible and may include nausea, vomiting, and reactions at the injection site.

What Is Naltrexone Injection?

Naltrexone injection (Vivitrol®) is a prescription opioid antagonist medication. It is used to help people who have stopped abusing alcohol and opioids remain drug-free.
Addiction is a complex illness that is best treated with a comprehensive addiction treatment program. Naltrexone injections should not be used alone. They are most effective when used as part of a complete addiction recovery program that also includes psychosocial treatment, such as counseling and support groups.
(Click What Is Naltrexone Injection Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, naltrexone injection can cause side effects. However, not everyone who uses the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common naltrexone injection side effects include but are not limited to:
  • Nausea
  • Vomiting
  • Injection-site reactions
  • Symptoms of the common cold.
(Click Naltrexone Injection Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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