Drugs Home > Ibritumomab

What If I Overdose on This Medicine?

An overdose with this medication can be dangerous. Seek immediate medical attention if you believe you may have been given too much ibritumomab.
(Click Zevalin Overdose for more information.)

What If I Miss a Dose of Ibritumomab?

If you miss an appointment to receive your ibritumomab dose, contact your healthcare provider right away to reschedule.

How Does This Medicine Work?

An antibody (also known as an immunoglobulin) is a protein made by the immune system. Antibodies attach to antigens, which are proteins found on certain molecules, marking the molecule for destruction by the immune system.
Ibritumomab is a synthetic (manufactured) antibody that binds to a specific antigen known as the CD20 antigen found on the surface of healthy and cancerous B-cells (a type of white blood cell). By binding to the CD20 antigen, ibritumomab signals the body to destroy the B-cells.
In addition, ibritumomab is linked to a radioactive element called the Y-90 isotope. The ibritumomab-Y-90 compound emits radiation that helps destroy both the B-cell the medicine is attached to and surrounding B-cells.

Clinical Effects

In clinical trials, ibritumomab has been shown to decrease the risk of disease progression in people with non-Hodgkin's lymphoma. In these studies, people who received ibritumomab after responding to first-line chemotherapy had a 54 percent decreased risk of their cancer progressing further, compared to people who did not receive any additional treatment.
In another study, 83 percent of people with relapsed or refractory non-Hodgkin's lymphoma responded to treatment with ibritumomab in combination with rituximab. By comparison, only 55 percent of people responded to rituximab treatment alone.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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