Drugs Home > What Is Gablofen Used For?

A healthcare provider may prescribe Gablofen to treat severe spasticity caused by multiple sclerosis, spinal cord injury, cerebral palsy, and other conditions. This medication is administered intrathecally (directly into the spinal cord) using a pump. If you have a traumatic brain injury, it may be best to wait to use Gablofen until at least one year has passed.

An Overview of Uses for Gablofen

Gablofen® (baclofen) is a prescription drug approved to treat spasticity. It is delivered directly into the spinal cord using a pump. This medicine is specifically approved to treat severe spasticity due to various causes, such as:
Milder forms of spasticity should be treated with oral baclofen.
Spasticity is the continual contraction of muscles. This can result in pain and loss of function, and can interfere with walking, speaking, and movement. Over time, the muscles may actually shorten, which can result in significant deformity, as well as severe loss of function. Spasticity is usually the result of damage to the brain or spinal cord.
When used to treat spasticity from a traumatic brain injury, it is usually recommended to wait at least a year after injury before considering intrathecal baclofen, including Gablofen. It is possible that only short-term treatment with oral baclofen will be necessary.

How Does This Medicine Work?

It is not fully understood exactly how Gablofen works to treat spasticity. Gablofen is chemically similar to gamma-aminobutyric acid (GABA), a chemical messenger in the central nervous system. The primary activity of GABA is to inhibit nerve signals, and Gablofen might have actions that are similar to GABA.
Giving Gablofen intrathecally delivers the medication directly into the spinal cord using a pump. This spares the rest of the body from the side effects of Gablofen to some extent.
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Last reviewed by: Kristi Monson, PharmD;
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