Drugs Home > Fondaparinux

Drug Interactions

This medication may potentially interact with a number of other medicines (see Drug Interactions With Fondaparinux).

What If I Overdose on Fondaparinux?

People who take too much of this medication may experience bleeding, including dangerous internal bleeding. Seek immediate medical attention if you or someone else may have overdosed on this medication.
(Click Arixtra Overdose for more information.)

How Does Fondaparinux Work?

Fondaparinux works by inhibiting a specific clotting factor known as factor Xa (pronounced "ten A"). It is more selective than heparin (including both unfractionated heparin and low molecular weight heparins), which inhibits other clotting factors as well. Notably, this medication does not affect blood platelets. It is not a heparin medication.
Like other "blood thinners," fondaparinux does not break down clots. Instead, it slows down clot formation, giving the body a chance to break down the clots naturally.

When and How to Take This Medication

Some general considerations include the following:
  • This medication is given as an injection just under the skin (as a subcutaneous injection) once a day.
  • The injections are usually given in the fatty layer on the abdomen (the "stomach" area).
  • If you are in a hospital, a healthcare provider will probably administer the injection. However, you may be sent home with this medication, in which case you or a caregiver must administer the injections.
  • Make sure your healthcare provider shows you exactly how to inject fondaparinux.
  • Do not inject this medication into a muscle. It should be injected into the fat layer under the skin.
  • For this drug to work properly, it must be taken as prescribed. You may be increasing your risk for serious problems if you stop taking it too soon.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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