Drugs Home > Dinoprostone Overdose

Strong or frequent uterine contractions, vomiting, and diarrhea are among the possible effects of an overdose on dinoprostone. The specific effects, however, will depend on how much of the drug was used and whether it was combined with other medications. Treatment would likely involve administering certain medications and treating any symptoms that occur.

Can You Receive Too Much Dinoprostone?

Dinoprostone (Cervidil®, Prepidil®, Prostin E2®) is a prescription medication used to soften and relax the cervix before labor and delivery in certain women. It is also used to vaginally remove pregnancy contents to cause an abortion or empty the uterus (womb) after a missed abortion or miscarriage. In addition, it may be used in women who have a cancer-like disease of the uterus known as nonmetastatic gestational trophoblastic disease.
As with any medication, it is probably possible to use too much dinoprostone. The effects of an overdose would likely vary, depending on a number of factors, including the dinoprostone dosage and whether it was combined with any other medications or substances.

Effects of an Overdose

Symptoms of a dinoprostone overdose may include:

Treatment Options for a Dinoprostone Overdose

The treatment for an overdose with dinoprostone will likely involve supportive care, which consists of treating the symptoms that occur as a result of the overdose. Supportive treatment may include administering oxygen, changing the mother's position, or giving certain medications to help manage strong contractions. Intravenous (IV) fluids may be given for severe fever, vomiting, and diarrhea.
It is important to seek medical attention immediately if you believe that you may have been given too much of this medication.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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