Drugs Home > Drug Interactions With Colesevelam
Drug interactions with colesevelam can occur if it is taken with warfarin, phenytoin, or vitamin K products, among other medicines. These interactions can decrease the absorption of these medications into the body, perhaps decreasing their effectiveness. To avoid drug interactions with colesevelam, take it at least four hours after taking other medicines that could interact with it.
Drug Interactions With Colesevelam: An OverviewColesevelam hydrochloride (WelChol®) has the potential to interact with a number of other medications. Some of the medications that can cause drug interactions with colesevelam include:
- Certain vitamins (vitamin A, D, E, and K)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Glimepiride (Amaryl®) or combination drugs that contain glimepiride (Avandaryl®, Duetact®)
- Glyburide (DiaBeta®, Glynase®, Micronase®)
- Levothyroxine (Levoxyl®, Levothroid®, Synthroid®, Tirosint®, Unithroid®)
- Metformin ER (Glucophage XR®, Glutametz®, and Fortamet®)
- Olmesartan (Benicar®) or combination drugs that contain olmesartan (Benicar HCT®, AZOR®)
- Oral contraceptives (birth control pills)
- Phenytoin (Dilantin®, Phenytek®)
- Warfarin (Coumadin®, Jantoven®).
These are just the known interactions with colesevelam. Because colesevelam has the potential to bind with and decrease the absorption of many drugs, you should talk with your healthcare provider about specific interactions that may be important in your situation. It is a good idea to take any medication that is important (such as an arrhythmia medication) at least four hours before a dose of colesevelam.