Drugs Home > Precautions and Warnings With Carbinoxamine Extended-Release Oral Suspension

To help minimize risks, make sure your healthcare provider is aware of your medical history and current medications before you take carbinoxamine extended-release oral suspension. Precautions with this allergy medicine include specific warnings for women who are nursing, those who have heart disease, and people with stomach ulcers. People with these and certain other medical issues may not be able to use this medicine.


What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking carbinoxamine extended-release oral suspension (Karbinal™ ER) if you have:
Also, let your healthcare provider know if you:
  • Drink alcohol
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Carbinoxamine Extended-Release Oral Suspension Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • There have been reports of deaths occurring in children under the age of two who took medicines containing carbinoxamine (the active ingredient in this drug). Therefore, carbinoxamine extended-release oral suspension should not be given to children who are younger than two years old.
  • Carbinoxamine extended-release oral suspension can cause significant drowsiness, which could affect your reflexes and reaction times. Do not drive, operate heavy machinery, or perform any activities that require mental alertness while taking this medicine. Alcohol and other medications that cause drowsiness may add to these effects and should not be used with carbinoxamine extended-release oral suspension.
  • This medication could worsen certain medical conditions, such as:
    • Conditions that cause increased pressure within the eye, such as glaucoma
    • Hyperthyroidism (an overactive thyroid)
    • Heart disease
    • High blood pressure
    • Stomach ulcers
    • Prostatic hypertrophy (an enlarged prostate)
    • Certain bladder problems that make it difficult to urinate (urinary bladder-neck obstruction)
    • A blockage of the lower part of the stomach (pyloroduodenal obstruction).
  • Carbinoxamine extended-release oral suspension contains a sulfite, which may cause serious allergic-type reactions in people who are sensitive to sulfites (this is not the same as having a "sulfa" allergy, which is an allergy to sulfonamide medications). The reactions can range from a life-threatening reaction known as anaphylaxis to mild asthma attacks. Although an allergy to sulfites is generally considered to be rare, it may be more common in people with asthma.
  • Each carbinoxamine extended-release oral suspension dose should be measured with an accurately marked measuring device, such as an oral syringe, medicine cup, or medicine spoon. A regular household spoon should not be used, as it is not accurate enough and could lead to an overdose. Your pharmacist can provide you with an appropriate measuring device and can show you how to correctly measure the dose.
  • Carbinoxamine extended-release oral suspension is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Karbinal ER and Pregnancy)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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