Drugs Home > C1 Esterase Inhibitor Dosage

Your C1 esterase inhibitor dosage will depend on the reason you are using the medication, the particular product you are using, and how much you weigh. This medicine is injected slowly into a vein, and can be administered by a healthcare provider or self-injected.


An Introduction to Your Dosage of C1 Esterase Inhibitor

The dose of C1 esterase inhibitor (Berinert®, Cinryze®) your healthcare provider recommends may vary, depending on the particular product you will be using and your weight. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

C1 Esterase Inhibitor Dosing Guidelines

It is important to note that each C1 esterase inhibitor product contains different concentrations of the active ingredient. Therefore, the dosing guidelines will depend on the exact medication you have been prescribed. You should refer to the product's instructions and follow your healthcare provider's dosing recommendations for the product you are using.
The usual recommended dosage of C1 esterase inhibitor (Cinryze) for the prevention of hereditary angioedema (HAE) attacks is 1000 units every three or four days. The medication is usually given slowly at a rate of 1 mL per minute, which normally takes 10 minutes to administer the dose.
The usual recommended dosage of C1 esterase inhibitor (Berinert) for the treatment of HAE attacks that have already started is 20 international units (IU) per kg body weight (about 9.09 IU per lb) at the first signs of an attack. Doses lower than 20 IU are not recommended. These injections are given slowly, at a rate of about 4 mL per minute.

General Information on Using C1 Esterase Inhibitor

Some considerations to keep in mind during treatment with C1 esterase inhibitor include the following:
  • C1 esterase inhibitor comes as a powder that is dissolved in sterile water for injection to form a liquid. It is given as a slow injection into a vein (an intravenous, or IV, injection).
  • The injections may be given by your healthcare provider, or (after proper training) self-injected. If you will be self-administering this medication, make sure you completely understand how to prepare it and inject it.
  • You should wash your hands before preparing your dose, and work on a clean surface to prevent contaminating the medicine with germs.
  • If you self-administer C1 esterase inhibitor to treat a laryngeal (voice box) attack, you should seek immediate medical attention after treating yourself. Laryngeal attacks can be life-threatening.
  • If you use the medication to treat an abdominal (stomach) attack, let your healthcare provider know afterwards so other possible causes of your symptoms can be excluded.
  • For the medication to work properly, it must be used as prescribed.
  • If you are unsure about anything related to your dosage, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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