Drugs Home > C1 Esterase Inhibitor and Breastfeeding

It is generally considered safe to use C1 esterase inhibitor products while breastfeeding. C1 esterase inhibitors may pass through breast milk in small amounts, but it is thought that the medicine would be destroyed in the infant's stomach before being absorbed into the bloodstream. However, you should still watch for any side effects in your child.


Can Breastfeeding Women Use C1 Esterase Inhibitor?

C1 esterase inhibitor (Berinert®, Cinryze®) is a prescription biologic medication approved to treat adults and teenagers with hereditary angioedema (HAE), a rare generic condition that causes swelling below the skin in various area of the body. At this time, it is unknown whether C1 esterase inhibitor passes through breast milk.

More Information on C1 Esterase Inhibitor and Breastfeeding

C1 esterase inhibitor medicines have not been adequately studied in breastfeeding women. Therefore, it is unknown whether it passes through breast milk or if it would harm a nursing child.
There have been reported cases of breastfeeding women using C1 esterase inhibitors to treat attacks associated with hereditary angioedema during breastfeeding. In these reports, no problems occurred in the nursing infants.
Based on the properties of the drug, it is not expected to pass through breast milk in large amounts. In addition, any small amount found in breast milk would likely not be absorbed into an infant's bloodstream, as the drug is expected to be destroyed in an infant's stomach or intestines before it can be absorbed.
In general, C1 esterase inhibitor medications are probably safe for use during breastfeeding. Some experts consider them the medications of choice for both treating and preventing hereditary angioedema attacks in women who are breastfeeding.
If your healthcare provider recommends breastfeeding during treatment with C1 esterase inhibitor, make sure to watch for any possible reactions in your nursing child. Let your child's healthcare provider know if your child develops any side effects, such as:
  • Rash
  • Nausea and vomiting
  • Fever
  • Difficulty feeding
  • Unexplained or excessive crying.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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