Drugs Home > Buprenorphine Injection Dosage

When using the buprenorphine injection for moderate-to-severe pain in adults, the usual dose is 1 mL injected every six hours. This injection can be injected into a muscle or given intravenously (by IV). The dosage amount for a child will be determined by the child's weight. Because children metabolize this medication quicker than adults, they may need more frequent doses.

An Introduction to Your Dosage of the Buprenorphine Injection

The dosage of the buprenorphine injection (Buprenex®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The type and severity of your pain
  • The type and dosage of other pain medications you have taken
  • Your weight (for children)
  • How you respond to the medication
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically tells you to do so.

Buprenorphine Injection Dosing Guidelines

The usual starting dosage of the buprenorphine injection for most people 13 years of age and older is 1 mL (0.3 mg) given by intramuscular injection (IM injection) or by intravenous infusion (IV). After the first dose, a repeat dose can be given after 30 to 60 minutes if needed to achieve adequate pain control. Thereafter, the medication is typically given every six hours as needed for pain relief.
In elderly people, people with breathing problems, or other individuals at high risk for serious buprenorphine injection side effects, a lower dose of 0.5 mL (0.15 mg) should be given, at least initially.
For some adults, a higher dosage of 2 mL (0.6 mg) may be necessary. A dosage this high should only be given by IM injection, not by IV.
For children age 2 to 12 years old, a healthcare provider will calculate an appropriate dose based on the child's weight. Interestingly, children may metabolize this medication more quickly than adults. In some cases, children may need more frequent doses (every four hours, instead of every six hours).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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