Drugs Home > Side Effects of Azelastine

Common side effects of azelastine that were seen in clinical studies included drowsiness, bitter taste, headaches, and nasal burning. There are also some side effects that, while occurring less frequently, are potentially serious and should be reported immediately to a healthcare provider. Seek medical attention if you experience azelastine side effects such as signs of an allergic reaction or excessive drowsiness.

Side Effects of Azelastine: An Introduction

As with any medicine, side effects are possible with azelastine hydrochloride nasal spray (Astelin®, Astepro). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article refers to azelastine nasal spray (Astelin or Astepro). For the eye drop form of this medication, see Optivar Side Effects. In addition, this article covers many, but not all, of the possible side effects with azelastine. Your healthcare provider can discuss a more complete list of azelastine side effects with you.)

Serious Azelastine Side Effects

Some side effects with azelastine, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Excessive drowsiness
  • An irregular heart rhythm (arrhythmia)
  • Feelings of a rapidly or forcefully beating heart (known as heart palpitations)
  • Signs of an allergic reaction, such as unexplained rash, hives, itching, and unexplained swelling. 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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