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Drug Interactions With Ketorolac

Drug interactions with ketorolac can increase your risk of serious side effects, make some drugs less effective, and cause your body to metabolize the drugs differently than intended, among other things. A few of the drugs that can potentially interact with ketorolac include psychoactive drugs, diuretics, and ACE inhibitors. Other drug interactions with ketorolac can occur with other nonsteroidal anti-inflammatory drugs (NSAIDs) and probenecid.

An Overview of Drug Interactions With Ketorolac

Ketorolac tromethamine (Toradol®) can potentially interact with a number of medicines. Some of these ketorolac drug interactions involve medications such as:
  • Angiotensin II receptor blockers (ARBs), such as:


  • Corticosteroids, including (but not limited to):
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)


      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)



  • Psychoactive drugs, such as:



Several herbal and nutritional supplements can also interact with ketorolac and may increase the risk of bleeding. Examples of these include (but are not limited to):
5 Common Pain Medication Fears

Ketorolac (Toradol)

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