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Precautions and Warnings With Doxylamine and Pyridoxine

Even though doxylamine and pyridoxine can be an effective "morning sickness" medicine, it may increase the risk for severe drowsiness, allergic reactions, and other problems. This medicine may not be safe for women who have stomach ulcers, asthma, or certain other medical conditions. Precautions and warnings for doxylamine and pyridoxine also apply to women who are nursing or who have difficulty passing urine.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking doxylamine and pyridoxine (Diclegis®) if you have:
  • Asthma
  • Increased pressure within the eye
  • Narrow angle glaucoma
  • A peptic ulcer (stomach ulcer)
  • An obstruction (blockage) at the lower end of the stomach (where it opens into the intestines)
  • Difficulty urinating
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are breastfeeding (see Diclegis and Breastfeeding).
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Doxylamine and Pyridoxine Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Doxylamine and pyridoxine can cause drowsiness, which could affect your reflexes and reaction times. Do not drive, operate heavy machinery, or perform any activities that require mental alertness until your healthcare provider tells you it is okay to do so.
  • You should not drink alcohol or take other medicines that can cause drowsiness while using doxylamine and pyridoxine. Doing so could cause significant drowsiness, potentially leading to falls or other accidents.
  • This medication could worsen certain medical conditions, including stomach ulcers, increased pressure within the eye (intraocular pressure), narrow angle glaucoma, blockage of the lower part of the stomach (pyloroduodenal obstruction), and certain bladder problems that make it difficult to urinate (urinary bladder-neck obstruction). Talk to your healthcare provider about taking this medication if you have any of these problems.
  • Doxylamine and pyridoxine is a pregnancy Category A medication, which means it is safe for use during pregnancy. The medication is intended for use in pregnant women (see Diclegis and Pregnancy).
  • Doxylamine and pyridoxine is expected to pass through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Diclegis and Breastfeeding).
Pregnancy and Pain

Doxylamine and Pyridoxine Drug Information

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