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Doxylamine and Pyridoxine

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
  • Asthma
  • Increased pressure within the eye (ocular hypertension)
  • Narrow angle glaucoma
  • A peptic ulcer (stomach ulcer)
  • An obstruction (blockage) at the lower end of the stomach (where it opens into the intestines)
  • Difficulty urinating
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are breastfeeding (see Diclegis and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Doxylamine and Pyridoxine to learn more, including information on who should not take the drug.)

Clinical Effects for Doxylamine and Pyridoxine

In clinical studies, doxylamine and pyridoxine was shown to reduce nausea and vomiting of pregnancy in women who were between 7 and 14 weeks gestation. In these studies, women who were given doxylamine and pyridoxine had a greater improvement in their nausea and vomiting symptoms after two weeks of treatment than those given a placebo (a "sugar pill" with no active ingredients). This included a reduction in the number of times a day they vomited or heaved, and how many hours they felt nauseous during the day.

How Does It Work?

It is not known how doxylamine and pyridoxine works to relieve nausea and vomiting of pregnancy. As mentioned, the medication contains a combination of doxylamine, an antihistamine, and pyridoxine, a form of vitamin B6. Pyridoxine helps relieve mild-to-moderate nausea, but does not reduce vomiting. Doxylamine, on the other hand, can help reduce vomiting.
Pregnancy and Pain

Doxylamine and Pyridoxine Drug Information

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