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Vandetanib Side Effects

Common Side Effects

Vandetanib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
In these studies, the most common vandetanib side effects included:
  • Diarrhea -- in up to 57 percent of people
  • Rash -- up to 53 percent
  • Acne -- up to 35 percent
  • Nausea -- up to 33 percent
  • High blood pressure (hypertension) -- up to 33 percent
  • Headache -- up to 26 percent
  • Fatigue -- up to 24 percent
  • Decreased appetite -- up to 21 percent
  • Stomach pain (abdominal pain) -- up to 21 percent.
Other common reactions, occurring in 9 to 15 percent of people, included:
  • Dry skin
  • Vomiting
  • Loss of energy or weakness
  • An abnormal heart rhythm
  • Increased sensitivity of the skin to sunlight
  • Insomnia
  • Symptoms of the common cold, such as stuffy or runny nose and sore throat
  • Heartburn or indigestion
  • Abnormally low blood calcium levels (hypocalcemia)
  • Cough
  • Itching
  • Weight loss
  • Abnormal amounts of protein in the urine
  • Depression
  • Blurred vision.

Final Thoughts

You may experience some or none of the vandetanib side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any adverse reactions while using vandetanib or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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Vandetanib Drug Information

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