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Drug Interactions With Vandetanib

Vandetanib Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when vandetanib is combined with any of the drugs mentioned above.
 
Colchicine
Vandetanib may increase blood levels of colchicine, which could increase your risk for potentially serious colchicine side effects. Your healthcare provider may choose to give you a lower colchicine dosage if you take these medicines together.
 
CYP 3A4 Inducer Medications
The body breaks down vandetanib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining vandetanib with one of these drugs may decrease the level of vandetanib in your body, potentially making it less effective. It is generally recommended that vandetanib not be combined with certain CYP 3A4 inducers known as strong inducers.
 
CYP 3A4 Inhibitor Medications
The body breaks down vandetanib using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining vandetanib with one of these drugs may increase the level of vandetanib in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects if you take these medicines together.
 
Dabigatran
Vandetanib may increase the level of dabigatran in your blood, potentially increasing your risk for bleeding. Your healthcare provider may need to lower your dabigatran dosage if you take it with vandetanib.
 
Everolimus
Vandetanib may increase the level of everolimus in your blood, potentially increasing your risk for everolimus side effects. Your healthcare provider may need to lower your everolimus dosage if you take these medications together.
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Vandetanib Drug Information

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