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Triphasil Drug Interactions

A number of medications can potentially interact with Triphasil. Drug interactions could increase your risk of developing side effects or increase your chance of unintentional pregnancy. Medicines that may cause an interaction include aprepitant, seizure medications, and cyclosporine, among others. If you are unsure about any particular Triphasil interaction, use a backup birth control method until you can talk to your healthcare provider.

An Introduction to Triphasil Drug Interactions

Triphasil® (levonorgestrel/ethinyl estradiol) can potentially interact with numerous other medicines. Many of these interactions can be severe enough to lead to unintentional pregnancy. In these instances, a backup method of birth control may be required. If you do not know what to do about any particular Triphasil drug interaction, be sure to use backup birth control until you can check with your healthcare provider, just to be safe. Some of the medicines that may lead to Triphasil interactions include:
  • Aminoglutethimide (Cytadren®)
  • Antibiotics
  • Aprepitant (Emend®)
  • Barbiturates, including (but not limited to):


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)






(Triphasil is equivalent to Enpresse® Levonest™, Myzilra™, and Trivora® birth control pills. The information in this article also applies to these medications.)
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