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Drug Interactions With TriNessa

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Click on an icon to view.Many Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in TriNessa too quickly, which could increase your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Modafinil (Provigil)
Modafinil may make TriNessa less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Protease Inhibitors
Using TriNessa with a protease inhibitor may increase your risk of pregnancy and may make the protease inhibitor less effective. Talk with your healthcare provider before combining these medications.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in TriNessa may increase the level of selegiline in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or recommend an alternate form of contraception.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of TriNessa, possibly increasing the chance of pregnancy. In general, you should not take St. John's wort while using TriNessa.
Theophylline (Uniphyl, Theocron, TheoCap, Theo-24, Elixophyllin)
TriNessa may increase the level of theophylline in your blood, possibly increasing the chance of theophylline side effects. Talk with your healthcare provider before taking these medications together. Your theophylline dose may need to be reduced, or you may need to switch to a different method of contraception.
It is possible that not all drug interactions with TriNessa were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to you.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD