Triglide has been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting Triglide and several months after treatment has started. These tests may also be recommended if your Triglide dosage is changed (see Triglide and Liver Problems).
Triglide can increase the cholesterol content in the bile, leading to gallstones. Your healthcare provider may choose to discontinue your Triglide prescription if gallstones are found in your body.
Triglide has been associated with a rare but serious condition known as rhabdomyolysis (severe breakdown of muscles). Your risk increases if you have kidney disease, are elderly, or are not being properly treated for hypothyroidism. Let your healthcare provider know immediately if you experience any muscle pain, tenderness, or weakness -- especially if they are accompanied by unexplained tiredness or a fever (see Triglide and Muscle Pain).
Triglide has been shown to cause a decrease in certain blood cells at the beginning of therapy. Your healthcare provider may decide to monitor your blood counts more closely during the first 12 months of your treatment.
Triglide is considered a pregnancy Category C medicine. This means that the drug has not been studied in pregnant women. However, when studied in animals, it did produce a negative effect on the fetus. If you are pregnant, you should take Triglide only if the benefit outweighs the possible risk to your unborn child. If you become pregnant while taking Triglide, contact your healthcare provider immediately.
It is not known whether Triglide passes through breast milk. But Triglide has been shown to increase the risk of tumors in nursing animals. Therefore, if you are nursing and taking Triglide, you are recommended to either stop breastfeeding or stop taking Triglide. This decision should be made by your healthcare provider.
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