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Triglide Drug Interactions

More Detail About Triglide Interactions

The following sections explain in detail the potentially negative interactions that may occur if Triglide is combined with any of the drugs listed above.
Warfarin (Coumadin, Jantoven)
Triglide can increase the anticoagulant effect of warfarin. This means that you are at an increased risk of bleeding if you are taking both Triglide and warfarin. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and make any necessary dosing adjustments. Prothrombin time and INR are tests used to measure how well your blood is clotting
HMG-CoA Reductase Inhibitors (Statins)
The use of Triglide with a statin medication should generally be avoided due to the increased risk of kidney and muscle problems. This combination should be used only if the benefit of further lowering cholesterol levels outweighs the risk.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Cyclosporine can make it more difficult for Triglide to be eliminated from the body. If you are taking both Triglide and cyclosporine, you may be at an increased risk of developing kidney problems (especially if you have kidney disease). Your healthcare provider may choose to monitor your progress more closely and make any necessary dosing adjustments.
Taking Triglide with colchicine may increase the risk of serious problems, including serious breakdown of muscle (rhabdomyolysis). In many cases, though, the benefits of taking Triglide with colchicine will outweigh the possible risks. Discuss these risks and benefits for your particular situation with your healthcare provider.
Bile Acid Sequestrants (Prevalite, Questran, Questran Light, LoCholest, Colestid, WelChol)
Bile acid sequestrants can bind to Triglide in the digestive tract and decrease its absorption into the body. Triglide should be taken at least one hour before or four to six hours after a bile acid sequestrant has been given to avoid this drug interaction.
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