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Tositumomab Side Effects

Some of the most commonly reported side effects of tositumomab include infections, weakness, and low blood cell counts. Although some people may not experience any reactions with this drug, most people will develop some type of side effect. It is important to be aware of the serious complications that might occur, such as fever, difficulty breathing, and unexplained bleeding, as these problems need prompt medical treatment.

An Introduction to Side Effects of Tositumomab

Just like any medicine, tositumomab (Bexxar®) may cause side effects, some of which can be significant. Although not everyone who receives this medicine will have problems, most people will experience some type of adverse reaction with this drug.
 
(This article covers many, but not all, of the possible side effects with tositumomab. Your healthcare provider can discuss a more complete list with you.)
 

Serious Tositumomab Side Effects

Some side effects of tositumomab are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Signs of an allergic or infusion reaction (a reaction that happens while receiving or soon after your dose), such as:
 
    • Fever and chills
    • An unexplained rash
    • Hives
    • Low blood pressure, which could cause dizziness
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Shortness of breath
    • Difficulty breathing or swallowing
    • Sweating
    • Stiffness
    • Nausea
 
  • Signs of infection, such as:
 
    • Fever
    • Chills
    • Aches and pains
    • A sore throat
    • Coughing
    • Painful urination
 
  • Signs of anemia, such as:
 
    • Unusual tiredness
    • Weakness
    • Pale skin
    • Shortness of breath
 
  • Unusual bleeding or bruising
  • Black, tarry or bloody stools
  • Small reddish or purple blood spots on your skin
  • Fatigue, increased sensitivity to the cold, or unexplained weight gain.
 
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Tositumomab Drug Information

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