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Tositumomab Dosage

Your healthcare provider will determine your dosage of tositumomab based on your platelet count and the blood levels of the drug after your first two doses. This medication comes as an injection that is given intravenously by your healthcare provider. A total of four infusions are given -- two of which are given in one day, followed by two more infusions one to two weeks later.

An Introduction to Your Dosage of Tositumomab

The dosage of tositumomab (Bexxar®) your healthcare provider recommends will vary, based on the following factors:
 
  • Your platelet count (as measured by a simple blood test)
  • How much tositumomab is absorbed in your bloodstream after your first two doses.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Tositumomab Dosing Guidelines

The usual tositumomab dosing regimen for the treatment of non-Hodgkin's lymphoma consists of four appointments with your healthcare provider, over one to two weeks. You will only receive your tositumomab dosages at two of these four appointments. During three of the appointments, you will receive a body scan that shows your healthcare provider how much and where tositumomab is in your body.
 
The following steps will happen during your four appointments:
 
  • At the first appointment, you will receive:

 

    • Tositumomab 450 mg, given as an intravenous (IV) infusion (a slow drip into a vein) over at least 60 minutes.
    • Tositumomab and Iodine I-131 given as an IV infusion over at least 20 minutes.
    • A body scan.
 
  • At your second and third appointments, you will receive a body scan only. You will not be given tositumomab at these appointments.
 
  • At your fourth appointment, you will receive:
 
    • Tositumomab 450 mg, given as an IV infusion over at least 60 minutes.
    • Tositumomab and Iodine I-131 given as an IV infusion over at least 20 minutes. Your healthcare provider will calculate this dosage based on your platelet count and the results of your body scans.
 
You will be given other medications by mouth (known as premedication) 30 minutes before receiving tositumomab, to help reduce the likelihood of infusion reactions (potentially serious reactions that may occur from the intravenous infusion). Premedication usually consists of acetaminophen (Tylenol®) 650 mg and diphenhydramine (Benadryl® and others) 50 mg, or other similar medications. If you experience infusion reactions, your healthcare provider may temporarily stop your infusion, or administer it more slowly.
 
Because tositumomab can damage the thyroid gland, you will be given other medicine to protect your thyroid starting at least 24 hours before your first dose of tositumomab and continuing for at least two weeks after your last dose of tositumomab. It is important to take this thyroid medicine as directed by your healthcare provider.
 
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Tositumomab Drug Information

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