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Drug Interactions With Tositumomab

More Detail on Drug Interactions With Tositumomab

The following sections explain in detail the potentially negative reactions that can occur when tositumomab is combined with any of the drugs listed above.
 
Amphotericin B
Combining tositumomab with amphotericin B could increase your risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and breathing problems. Your healthcare provider may choose to monitor you more closely if you use these medications together.
 
Clozapine
Using clozapine and tositumomab together may increase the risk for dangerously low white blood cells, which would increase your risk for infections. Talk to your healthcare provider before using these medicines together.
 
Digoxin
Digoxin may decrease the amount of digoxin absorbed into the bloodstream, which could make digoxin less effective. Your healthcare provider may choose to monitor you more closely if you use these medicines together, and adjust your digoxin dosage if necessary.
 
Biologic and Immunologic Medications
Combining tositumomab with other medications that suppress the immune system may increase the risk for side effects, such as infections, anemia, or bleeding problems. Your healthcare provider may want to monitor you more closely if you use these medicines together.
 
Echinacea
Echinacea can make tositumomab less effective. This is because echinacea is thought to stimulate the activity of the immune system, while tositumomab works by suppressing the activity of the immune system. Talk to your healthcare provider before taking echinacea during tositumomab treatment.
 
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while using tositumomab, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people receiving tositumomab. Talk to your healthcare provider before receiving a vaccination during or within the first few months after tositumomab therapy.
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