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Tocilizumab Dosage

If you are using tocilizumab for rheumatoid arthritis, your dosage may be administered in one of two ways: through an IV infusion (also known as an IV drip) or a subcutaneous injection. For the other approved uses, it is only administered through an IV infusion. Your healthcare provider will determine your amount based on your weight, the condition being treated, and other factors.

An Introduction to Dosing With Tocilizumab

The dose of tocilizumab (Actemra®) your healthcare provider recommends may vary, depending on how you respond to the medication (especially if you develop certain side effects) and on your weight. As is always the case, do not adjust your dosing schedule (by missing or canceling doses) unless your healthcare provider specifically instructs you to do so.

Recommended Tocilizumab Dosage for Rheumatoid Arthritis

When used to treat rheumatoid arthritis, tocilizumab can be given either by IV or as a subcutaneous injection.
The recommended starting dosage of tocilizumab for rheumatoid arthritis treatment in adults is 4 mg per kg (about 1.8 mg per pound) once every four weeks. Your healthcare provider may increase the amount up to 8 mg per kg (about 3.6 mg per pound) once every four weeks. The medication is administered intravenously via an IV infusion (also known as an IV drip) lasting one hour. The maximum dosage is 800 mg per IV infusion.
For subcutaneous injection, the standard dosage is 162 mg (one prefilled syringe) once a week for people weighing 220 pounds or more. For people who weigh less than 220 pounds, the drug is started at 162 mg once every other week, increasing to once a week if necessary and tolerated.
Your healthcare provider should check your liver function and blood cell counts (using standard blood tests) before you start tocilizumab and periodically thereafter. If your liver enzymes are too high or your blood cell counts are too low, your dosage may need to be reduced (in mild cases), or you may need to stop taking this medication altogether (for more severe cases).
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Tocilizumab Drug Information

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