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Drug Interactions With Tobramycin Inhalation Solution

More Detail on Drug Interactions With Tobramycin Inhalation Solution

The following sections explain in detail the potentially negative reactions that can occur when any of the drugs mentioned above are combined with tobramycin inhalation solution.
 
Amphotericin B
Using tobramycin inhalation solution with amphotericin B could increase your risk for kidney problems. Your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you use these medicines together.  
 
Bisphosphonates
Combining a bisphosphonate with tobramycin inhalation solution could lead to low blood calcium levels (hypocalcemia). If you use these medicines together, your healthcare provider may choose to monitor you for this potential side effect.
 
Carboplatin
Because both tobramycin inhalation solution and carboplatin can cause inner ear damage, using them together could increase the risk for this side effect. Talk to your healthcare provider before using these medicines together.
 
Cephalosporin Antibiotics
Combining tobramycin inhalation solution with a cephalosporin could increase your risk for kidney problems. Your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you use these medicines together.  
 
Cisplatin
Combining tobramycin inhalation solution with cisplatin could increase the risk for kidney problems. Your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you use these medicines together.  
 
Colistimethate
Combining tobramycin inhalation solution with a colistimethate could increase your risk for certain side effects, including kidney problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.  
 
Cyclosporine
Taking tobramycin inhalation solution with cyclosporine could increase your risk for kidney problems. Your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you use these medicines together.  
 
Gallium Nitrate
Combining tobramycin inhalation solution with gallium nitrate could increase the risk for kidney problems. It is recommended that these medicines not be used together if at all possible. If you need to take both medicines, your healthcare provider will closely monitor your kidney function using blood and urine tests.
 
Loop Diuretics
Taking loop diuretics with tobramycin inhalation solution could increase the chance that you will experience tobramycin inhalation solution side effects, including kidney and ear problems. Talk to your healthcare provider before using these medicines together. Your healthcare provider may want to monitor you more closely for potential side effects.
 
Mannitol
The manufacturer of tobramycin inhalation solution recommends that it should not be used in combination with mannitol, as using these medications together could increase the risk for tobramycin inhalation solution side effects.
 
Neuromuscular-Blocking Medications
Combining tobramycin inhalation solution with a neuromuscular-blocker could increase your risk for certain serious side effects, including abnormally slow and shallow breathing. Your healthcare provider will need to monitor you closely if you use these medicines together.
 
NSAIDs
Taking tobramycin inhalation solution with an NSAID may increase the risk for kidney problems. This interaction appears to mainly be a concern in premature infants. However, your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you take these medicines together, just to be safe.  
 
Other Aminoglycoside Antibiotics
Using tobramycin inhalation solution with other aminoglycoside antibiotics could increase your risk for side effects. You may need to be monitored more closely if you are using more than one aminoglycoside medication at the same time.
 
Vancomycin
Combining tobramycin inhalation solution with vancomycin could increase the risk for kidney problems. Your healthcare provider may choose to monitor your kidney function more closely using blood and urine tests if you use these medicines together.  
 

Tobramycin Nebulizer Information

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