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Thalomid Dosage

Recommended Thalomid Dosage for Erythema Nodosum Leprosum

The usual recommended dosage of Thalomid for the treatment of erythema nodosum leprosum (a skin reaction associated with leprosy) is between 100 mg and 300 mg taken once a day. People who weigh less than 50 kg (110 lb) are normally started at the lower end of the dosing range.
People who have a severe skin reaction or who have needed high doses in the past to control their skin reaction may be given higher doses, up to 400 mg daily. This high dose can be given as a once-daily dose, or divided up throughout the day, as long as each dose is taken at least one hour after a meal.
Treatment normally continues until the skin reaction is no longer present, which usually requires at least two weeks of treatment. At that time, the medication should be slowly reduced by 50 mg every two to four weeks.
However, some people may need to take Thalomid for long periods of time to prevent skin reactions from returning. In these cases, the lowest effective dosage should be used, and an attempt to stop the medication should be tried every three to six months, by reducing the dosage by 50 mg every two to four weeks.

Thalomid Prescribing and Dispensing Restrictions

Because of the high risk of birth defects due to this medication, there are strict regulations for prescribing and dispensing it. These rules are designed to prevent pregnant women from being exposed to the drug. Some of these requirements include the following:
  • You will have to sign special paperwork and take periodic phone surveys to ensure you are following the rules.
  • Your prescriber will need to call the manufacturer to receive authorization each month before you can have a new prescription.
  • Your pharmacy must be registered with a special program in order to dispense Thalomid, and your pharmacist will have to call to get each prescription authorized by the manufacturer (again) before dispensing the medication.
  • No refills or phone-in prescriptions are allowed (a new prescription is required each month), and only 28 days' worth of medication can be dispensed at a time.
This process can be confusing and tricky, especially because each step is time-sensitive (each authorization is only good for a short period of time). Make sure your pharmacist and prescriber can work together to make the process run smoothly.
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Thalomid Medication Information

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