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Temozolomide Side Effects

Clinical trials on temozolomide have shown that side effects are likely to occur in most people undergoing chemotherapy treatment with this drug. Some of the most commonly reported problems include decreased white blood cells, vomiting, and hair loss. In addition, it's important to seek medical treatment if you develop extreme weakness, persistent diarrhea, or other serious problems.

An Introduction to Side Effects of Temozolomide

As with any chemotherapy medicine, temozolomide (Temodar®) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some side effects can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with temozolomide. Your healthcare provider can discuss a more complete list with you.)

Serious Temozolomide Side Effects

Some side effects of temozolomide are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing
  • Signs of infection, such as:
    • Fever
    • Chills
    • Aches and pains
    • Sore throat
    • Shortness of breath
    • Cough
  • Signs of anemia, such as:
    • Extreme weakness or fatigue
    • Pale skin
    • Shortness of breath
    • Dizziness
  • Signs of liver problems, such as:
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Dark urine
    • Pale stool
    • Upper-right abdominal (stomach) pain
  • Persistent nausea, vomiting, or diarrhea
  • Numbness, tingling, or burning sensations
  • Seizures
  • Unusual bleeding or bruising
  • Black, tarry stools or blood in the urine
  • Sores, ulcers, or blisters in the mouth or throat
  • Feelings of paralysis or weakness on one side of your body
  • Pain or burning when you urinate
  • Swelling, burning, pain, redness, or leakage of fluid around your infusion site (if you receive this medicine as an injection).
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Temozolomide Drug Information

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