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Temozolomide Dosage

The guidelines for calculating the appropriate dosage of temozolomide are highly individualized and will largely depend on height and weight. Other factors affecting the amount include the reason you are using it and how you respond to the medication. Temozolomide comes as a capsule that is taken by mouth or as an injection that is given slowly into a vein.

An Introduction to Your Dosage of Temozolomide

The dose of temozolomide (Temodar®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your height and weight
  • The reason you are taking it
  • How you respond to and tolerate the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Temozolomide Dosing Guidelines for Glioblastoma Multiforme

Like many chemotherapy medicines, temozolomide dosing is based on body surface area, which is normally calculated using your height and weight. Doses based on body surface area are expressed as milligrams per meter squared (mg per m2).
The initial recommended dosage of temozolomide for the treatment of newly diagnosed glioblastoma multiforme (a type of brain tumor) is usually 75 mg per m2 daily for 42 days, in combination with radiation treatment. Some people may need to take the medicine for up to 49 days. Four weeks later, you may be given six cycles of maintenance treatment, as follows:
  • Cycle 1: Temozolomide 150 mg per m2 daily for 5 days, followed by a 23-day break in treatment
  • Cycles 2 through 6: Temozolomide 200 mg per m2 daily for 5 days, followed by a 23-day break in treatment.
Your healthcare provider will do blood tests and monitor you for side effects before each treatment cycle. If you develop potentially serious temozolomide side effects, such as low blood cell counts, your healthcare provider may reduce your dosage, delay your treatment, or recommend you stop taking the medication altogether.
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Temozolomide Drug Information

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