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Tacrolimus Overdose

It is possible for someone to use too much tacrolimus. The overdose effects will vary, based on certain factors. Possible symptoms include hives, tremors, and kidney problems. Treatment will typically involve supportive care to treat any symptoms that occur as a result of the overdose, in addition to pumping the stomach.

Can You Take Too Much Tacrolimus?

Tacrolimus (Prograf®, Protopic®) is a prescription medication in a class of medicines called immunosuppressants. Like other immunosuppressants, it decreases the activity of the immune system. As with any medicine, it is possible to overdose on tacrolimus.
 
The specific effects of an overdose can vary, depending on a number of factors, including the tacrolimus dosage and whether it was taken with any other medications or substances.
 

Effects of an Overdose

There have been reports of overdoses of up to 30 times the recommended tacrolimus dose. Based on these cases, possible overdose symptoms may include but are not limited to:
 
 
These symptoms are unlikely to occur from a tacrolimus ointment overdose, however, as very little of the medicine is absorbed through the skin into the bloodstream. Using too much tacrolimus ointment could cause skin irritations, such as redness, stinging, burning, and itching. If large amounts of the ointment are taken by mouth, overdose symptoms also could occur.
 

Treatment for a Tacrolimus Overdose

The treatment for an overdose of tacrolimus may vary. If the overdose was recent and taken by mouth, a healthcare provider may "pump the stomach" to help reduce the amount of the drug absorbed into the bloodstream. Dialysis is not expected to be helpful for removing tacrolimus from the bloodstream.
 
Treatment will also include supportive care, which consists of treating the symptoms that occur as a result of the overdose. For example, supportive treatment for a tacrolimus overdose may include:
 
 
It is important that you seek medical attention immediately if you believe that you or someone else may have overdosed on this medication.

Tacrolimus Drug Information

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