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Tacrolimus Dosage

Tacrolimus Dose Adjustments for Transplant Rejection

Your healthcare provider will monitor your tacrolimus blood levels, and may adjust your dosage to keep your blood levels within the recommended range. This amount may also be adjusted if you are experiencing side effects or showing signs of transplant rejection. The goal is to find the best dose for you that prevents transplant rejection while minimizing side effects.

Dosage of Tacrolimus for Atopic Dermatitis

The usual recommended dose of tacrolimus ointment for the treatment of moderate-to-severe atopic dermatitis (eczema) is a thin layer of medicine applied to the affected area(s) of the skin twice a day. Symptoms, such as itching and redness, should improve within six weeks of beginning treatment. If your symptoms do not improve, contact your healthcare provider. You may have a condition other than atopic dermatitis.
You should avoid bathing, showering, or swimming immediately after applying the ointment so you don't wash the medicine off your skin. Also, do not cover the treated area with bandages or other dressings. Doing so could cause you to absorb too much medicine through your skin into your body.
Because it is associated with potentially serious side effects, such as skin cancer and lymphoma, tacrolimus ointment should only be used on areas of the skin that have eczema and only for a short time. The medication should be stopped when your symptoms subside, unless your healthcare provider tells you otherwise. Your healthcare provider may recommend you use the ointment again, if necessary, after a break.

General Information on Taking Tacrolimus

Some considerations to keep in mind during treatment with tacrolimus include the following:
  • This medication comes as a capsule, an intravenous (IV) solution, and an ointment. The capsules are taken by mouth twice daily, 12 hours apart. The ointment is applied to the skin twice daily. The injection is given as a continuous slow infusion into a vein over two to six hours.
  • You can take oral tacrolimus with or without food; however, it should always be taken the same way so that the same amount of time between doses and meals is consistent every day.
  • When using tacrolimus ointment, use the smallest amount needed to apply a thin layer to the affected area of skin. Applying more than necessary or using the medicine more often than directed will not make it work faster, but it may increase your risk for side effects.
  • Wash your hands before applying the ointment, and again afterward if you are not treating your hands.
  • Only apply tacrolimus ointment to areas of your skin with eczema, and stop using the ointment when your symptoms clear, unless your healthcare provider tells you otherwise.
  • If you are using a moisturizer with tacrolimus ointment, apply the ointment first. Talk to your healthcare provider about the best moisturizer for your skin.
  • For this drug to work properly, it must be used as prescribed.
  • If you are unsure about anything related to dosing with tacrolimus, please talk to your healthcare provider or pharmacist.

Tacrolimus Drug Information

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