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Drug Interactions With Tacrolimus

More Detail on Drug Interactions With Tacrolimus

The following sections explain in detail the potentially negative interactions that can occur when tacrolimus is combined with any of the drugs listed above.
If you drink alcohol while using tacrolimus ointment, it can cause your face and neck to become flush (red and warm), especially on the areas of the skin where you apply the medication.
Certain Blood Pressure Medicines
Combining tacrolimus with ACE inhibitors could increase your risk for kidney problems and high blood potassium levels. Taking tacrolimus with a calcium channel blocker may increase blood levels of both medicines. Talk with your healthcare provider before taking these drugs together. This interaction is less likely to occur with tacrolimus ointment.
Tacrolimus may increase the amount of colchicine in your bloodstream, which could increase your risk for potentially serious colchicine side effects. Talk to your healthcare provider before taking these medicines together. You may need a lower colchicine dosage. This interaction is not likely to occur with tacrolimus ointment.
Combining cyclosporine and tacrolimus could increase the blood levels of both medicines and increase your risk for kidney problems. Oral tacrolimus should not be taken with cyclosporine, or within 24 hours of taking cyclosporine. Although this interaction is less likely to occur with tacrolimus ointment, there is a potentially serious risk, and your healthcare provider may choose to monitor you more closely if you use these medicines together.
CYP 3A4 Inducer Medications
The liver breaks down tacrolimus using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining tacrolimus with one of these drugs may decrease the level of tacrolimus in your body, potentially making it less effective. Your healthcare provider may need to adjust your tacrolimus dosage, especially when you first start or stop taking a CYP 3A4 inducer. This interaction is not a concern with tacrolimus ointment.

Tacrolimus Drug Information

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