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Drug Interactions With Tacrolimus Ointment

More Detail on Drug Interactions With Tacrolimus Ointment

The following sections explain in detail the potentially negative reactions that can occur when tacrolimus ointment is combined with any of the drugs listed above.
 
Alcohol
Drinking alcohol while using tacrolimus ointment may cause facial flushing, which is a sudden redness and warmth of the skin on the face and neck. The flushing is most likely to occur on the areas where you apply the medication.
 
Cyclosporine
Combining cyclosporine and tacrolimus ointment may increase your blood levels of both medicines and could increase your risk for kidney problems. Because it is a skin ointment, very little tacrolimus ointment is absorbed into the body with normal use. However, this drug interaction is potentially serious, so your healthcare provider may choose to monitor you more closely, or give you a different medicine rather than have you take cyclosporine while using tacrolimus ointment.
 
Calcium Channel Blockers
Taking tacrolimus ointment with a calcium channel blocker could increase the level of tacrolimus ointment in your body. Although very little of the drug is absorbed into the body with normal use, your healthcare provider may choose to monitor you more closely if you use tacrolimus ointment while taking a calcium channel blocker. This reaction is more likely to occur with diltiazem and verapamil, or when tacrolimus ointment is used on large areas of the body.
 
CYP 3A4 Inhibitor Medications
The body breaks down tacrolimus ointment using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining tacrolimus ointment with one of these drugs may increase the level of tacrolimus ointment in your body, potentially increasing your risk for side effects.
 
The risk for this reaction is generally low because very little tacrolimus ointment is expected to be absorbed into the body with normal use. However, your healthcare provider may choose to monitor you more closely if you take tacrolimus ointment with a CYP 3A4 inhibitor.

Tacrolimus Ointment Information

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