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What Is Streptozocin Used For?

How Does This Medicine Work?

Streptozocin belongs to a group of medications called alkylating agents. More specifically, it is a nitrosourea alkylating agent. Like other alkylating agents, streptozocin transfers a piece of its structure, called an alkyl group, to DNA. This causes the strands of DNA to bond to each other and become linked (this is called "cross-linking").
 
The linked DNA strands cannot uncoil and separate, which is necessary for the DNA to replicate. Because DNA replication is essential for cells to grow and multiply, alkylating medications like streptozocin prevent cell growth and multiplication.
 

Can Children Use It?

Streptozocin is approved for use in children. However, pancreatic tumors in children are quite rare, so the use of this medicine in children is unlikely. Talk to your child's healthcare provider about the risks and benefits of using this medication in a child.
 

Is It Safe for Older Adults to Use Streptozocin?

Yes -- older adults can use streptozocin. There were not enough people aged 65 and older in clinical trials to determine if older adults respond differently to the medicine than younger age groups.
 
However, because older adults are more likely to have other medical conditions and to be taking other medicines, they may need more careful monitoring. Older adults may also need lower initial streptozocin doses.
 

What About Off-Label Uses?

On occasion, your healthcare provider may recommend this drug for treating something other than pancreatic islet cell cancer. This is called an "off-label" use. For example, streptozocin may be used off-label to treat the following conditions:
 
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Streptozocin Drug Information

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