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Drug Interactions With Sirolimus

Taking denosumab with sirolimus could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these drugs together. Also, contact your healthcare provider if you develop any signs of infection, such as fever, chills, aches and pains, or coughing.
Echinacea could decrease the effectiveness of sirolimus. Do not take echinacea while taking sirolimus without first talking with your healthcare provider.
Combining leflunomide with sirolimus may increase your risk for blood cell problems, such as abnormally low red blood cells, white blood cells, and platelets. Talk to your healthcare provider before taking these medicines together.
Live Vaccinations
Talk to your healthcare provider before receiving any vaccination while taking sirolimus. You should not receive a "live" vaccine during treatment. The vaccine may not work as well.
Combining sirolimus with natalizumab may increase your risk for infections. You should not take these medicines together unless your healthcare provider tells you otherwise.
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of body tissues, so they can be excreted through the urine or feces. Pgp helps remove sirolimus from the body. Medications known as Pgp inducers increase the activity of Pgp.
When sirolimus is taken with a Pgp inducer, it may be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take sirolimus with a Pgp inducer and adjust your dose as needed.

Sirolimus Drug Information

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