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Drug Interactions With Sirolimus

More Details on Drug Interactions With Sirolimus

The following sections explain in detail the potentially negative interactions that can occur when sirolimus is combined with any of the drugs listed above.
 
ACE Inhibitors
Combining sirolimus with an angiotensin-converting enzyme (ACE) inhibitor may increase your risk for a serious allergic reaction known as angioedema. Angioedema is swelling, much like hives, which occurs below the skin. Contact your healthcare provider immediately if you develop hives, red welts, or swelling of the eyes, lips, tongue, throat, hands, or feet, as these could be signs of angioedema.
 
Cyclosporine
Combining cyclosporine with sirolimus may increase your blood levels of sirolimus, potentially increasing your risk for side effects. To help reduce the risk of this interaction, sirolimus should be taken four hours after cyclosporine.
 
CYP 3A4 Inducer Medications
The body breaks down sirolimus using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining sirolimus with one of these drugs may decrease the level of sirolimus in your body, potentially making it less effective. Your healthcare provider may need to adjust your sirolimus dosage, especially when you first start or stop taking a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The body breaks down sirolimus using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining sirolimus with one of these drugs may increase the level of sirolimus in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take sirolimus with a CYP 3A4 inhibitor and adjust your dose as needed.

Sirolimus Drug Information

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