Simvastatin Alternatives

If side effects occur, or if you do not respond well to simvastatin, alternatives to the medication are available. A number of other medicines used for treating high cholesterol include other statins (the class of drugs that simvastatin belongs to), fibrates, bile acid sequestrants, nicotinic acid, and cholesterol absorption inhibitors. You may have better results with one of these alternatives.

Are There Alternatives to Simvastatin?

Lifestyle changes are the first line of treatment for
 lowering cholesterol. However, for some people, treating high cholesterol with diet, weight control, and exercise alone is not enough. In this case, your healthcare provider can prescribe cholesterol medications. One such medicine is simvastatin (Zocor®). For most people, simvastatin is quite effective at lowering cholesterol. It is also generally well tolerated. However, side effects can occur and people may wish to consider an alternate to simvastatin. These substitutes could include other statins or other cholesterol medicines.
 
Other Statins
Simvastatin is part of a class of drugs called statins (or HMG-CoA reductase inhibitors). Statins work by blocking a particular enzyme, HMG-CoA reductase, that controls the rate of cholesterol production in the body. This causes the liver to make less cholesterol. Simvastatin also:
 
Several statin medications are available that could be considered an alternative for simvastatin. These include:
 
There are also several generic versions of these prescription statins, including simvastatin (see Generic Simvastatin). To see if a generic statin would make sense in your situation, talk to your healthcare provider.
(Simvastatin Alternatives Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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