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Drug Interactions With Simvastatin

Antifungals
There is a possibility that when simvastatin is taken with antifungals, you are at a higher risk of developing muscle problems. Simvastatin should not be taken with itraconazole, ketoconazole, or posaconazole. If you are on simvastatin and need to take one of these medications, you will need to stop taking simvastatin, at least temporarily.
 
Erythromycin, Clarithromycin, or Telithromycin
Taking simvastatin with erythromycin, clarithromycin, or telithromycin is not recommended. This can cause significant reactions, including increasing the risk of developing serious muscle problems like myopathy or rhabdomyolysis. If you are on simvastatin and need to take one of these medications, you will need to stop taking simvastatin, at least temporarily.
 
HIV Protease Inhibitors
Taking simvastatin with an HIV protease inhibitor is not recommended. This can cause significant reactions. Among other things, it can increase the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Ranolazine
Combining ranolazine with simvastatin may increase the risk of serious muscle problems (such as myopathy or rhabdomyolysis). If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your dosage of simvastatin should not exceed 20 mg.
   
Nefazodone
Taking both simvastatin and nefazodone is not recommended. This can cause significant reactions. Among other things, it can increase the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
Amiodarone
Taking amiodarone and simvastatin together may cause your body to metabolize the medicines differently than intended. This can cause significant reactions. Among other things, it can increase the risk of developing serious muscle problems like myopathy or rhabdomyolysis.
 
If you are taking these medicines together, your healthcare provider may choose to monitor your progress closely and make necessary dosing adjustments. Your simvastatin dosage should not exceed 20 mg.
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