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Sandimmune Drug Interactions

More Information on Sandimmune Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when Sandimmune is combined with any of the drugs listed above.
 
Aliskiren
Sandimmune can increase the amount of aliskiren in your blood, possibly increasing your risk for side effects. These medicines should not be taken together.
 
Allopurinol
Allopurinol may increase the level of Sandimmune in your blood, potentially increasing your risk for Sandimmune side effects. Do not take these drugs together without first talking to your healthcare provider.
 
Certain Blood Pressure Medicines
Taking Sandimmune with an angiotensin-converting enzyme (ACE) inhibitor could increase your risk for kidney problems, especially if you are dehydrated, which could happen if you do not consume enough fluids. Taking Sandimmune with a calcium channel blocker may increase blood levels of both drugs. Therefore, talk with your healthcare provider before taking Sandimmune with an ACE inhibitor or calcium channel blocker.
 
Colchicine
Combining Sandimmune with colchicine can increase the amount of colchicine in your body, increasing your risk for potentially serious side effects. Talk to your healthcare provider before taking these drugs together. Your healthcare provider may need to lower your colchicine dosage.
 
CYP 3A4 Inducer Medications
The body breaks down Sandimmune using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Sandimmune with one of these drugs may decrease the level of Sandimmune in your body, potentially making it less effective. Your healthcare provider may need to monitor you more closely if you take Sandimmune with a CYP 3A4 inducer.

Sandimmune Medication Information

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