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Sandimmune Dosage

Your weight plays a significant role in the dose of Sandimmune you are prescribed; however, other factors are also taken into consideration. Sandimmune comes in three different forms, and it is given 4 to 12 hours before the transplant surgery. Afterwards, the drug is taken once a day for up to two weeks, and then dosing is adjusted until a maintenance amount is determined.

An Introduction to Your Sandimmune Dosage

The dose of Sandimmune® (cyclosporine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your weight
  • Your Sandimmune blood levels
  • How you respond to the medication.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Dosing for Sandimmune Capsules and Oral Solution

The recommended initial dosage of Sandimmune capsules and oral solution to prevent organ transplant rejection is 15 mg per kg (6.8 mg per pound) given 4 to 12 hours before transplantation. Initial amounts may be lower in some people, especially after a kidney transplant, ranging from 10 to 14 mg per kg per day (4.5 to 6.4 mg per pound).
The initial dose is usually continued once a day for one to two weeks, and then slowly decreased by 5 percent each week to a maintenance dose of 5 to 10 mg per kg per day (2.3 to 4.5 mg per pound). The maintenance amount may be as low as 3 mg per kg (1.4 mg per pound) in people who have had a kidney transplant.
Your healthcare provider will follow you closely to determine the best individual dosage for you. The goal is to find an amount that prevents transplant rejection, while avoiding potentially serious or intolerable side effects. Your actual dosage will depend on your Sandimmune blood levels, any side effects you experience, and any evidence of transplant rejection.
Children may receive the same Sandimmune dosage as adults. But in some cases, they may need higher doses.
Sandimmune is used in combination with a corticosteroid medicine, such as prednisone. You will be started on a high corticosteroid dose, which will be slowly reduced over a couple of months to a lower maintenance dose.

Sandimmune Medication Information

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