Interactions With Rosuvastatin Explained
The following sections explain in detail the potentially negative interactions that can occur when
rosuvastatin is combined with any of the drugs listed above.
Antacids
If you are using
antacids while taking rosuvastatin, make sure to take the antacid at least two hours after rosuvastatin. Antacids may decrease the absorption of rosuvastatin into your system, perhaps making it less effective.
Birth Control Pills
Taking
birth control pills with rosuvastatin can increase the level of the hormones in the birth control pills, perhaps increasing your risk of side effects. Be sure to discuss this with your healthcare provider if you are currently using birth control pills.
Cimetidine
Theoretically, rosuvastatin may decrease the level of steroid hormones in the body. Since
cimetidine can also lower these hormone levels, taking these medications together may increase your risk of related problems. Talk to your healthcare provider before combining cimetidine with rosuvastatin.
Cyclosporine
Taking cyclosporine and rosuvastatin simultaneously may greatly increase the level of rosuvastatin in your blood. This can increase your risk of
rosuvastatin side effects, including serious muscle problems, such as myopathy or rhabdomyolysis
(see Crestor and Muscle Pain). Your healthcare provider may choose to monitor your progress more closely and make necessary dosing adjustments.
Fibrates
Taking a fibrate and rosuvastatin at the same time may increase the level of rosuvastatin in your blood. This can increase your risk of rosuvastatin side effects, including serious muscle problems, such as myopathy or rhabdomyolysis
(see Crestor and Muscle Pain). In general, rosuvastatin should not be taken with a fibrate. However, if your healthcare provider recommends taking these medications together, the maximum recommended dose of rosuvastatin is lower than usual (10 mg per day).
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