Drug Interactions With Risedronate and Calcium

Drug interactions with risedronate and calcium may occur if it is combined with aspirin, ibuprofen, or thyroid medications. These interactions can lead to reduced effectiveness of risedronate or an increased risk of side effects. To reduce your risk of drug interactions with risedronate and calcium, do not eat or drink anything (besides water) before taking risedronate and for 30 minutes afterward.

Drug Interactions With Risedronate and Calcium: An Overview

 Risedronate and calcium (Actonel® With Calcium) can potentially interact with a number of other medications. Many interactions can make the drug less effective, while others may increase the risk of side effects. Some of the medicines that may lead to drug interactions with risedronate and calcium include:
 
  • Aspirin
  • Calcium products, including many antacids
  • Fluoroquinolone antibiotics, such as:
 
 
  • Iron supplements
  • Magnesium products
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Thyroid medications, such as:
 
 
Food and beverages (other than water) can also interact with risedronate (the orange tablets that are taken once a week), preventing it from being absorbed into the body and making it less effective. Risedronate should be taken with water in the morning on an empty stomach. Do not eat or drink anything (besides water) before taking the drug and for 30 minutes afterward. On the other hand, the calcium tablets (the blue tablets that are taken the other six days of the week) should be taken with food.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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