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Qualaquin Drug Interactions
Several drugs can cause negative interactions with Qualaquin, including antacids, blood pressure medications, and some statin medicines. Some of these reactions can alter the amount of the medications in the blood, possibly making them less effective or increasing your risk for side effects. Before starting treatment with Qualaquin, make sure to let your healthcare provider know about any other medications, herbs, or supplements you are taking.
Qualaquin® (quinine sulfate) is a prescription medication licensed to treat uncomplicated (or mild) malaria. This medication may potentially interact with many other medications, far too many to include in this article.
This article includes some of the more dangerous or common interactions. Some of the medications that may lead to Qualaquin drug interactions include but are not limited to:
- Antacids
- Blood pressure medications
- Certain other antimalarials, such as:
- Artemether-lumefantrine (Coartem®)
- Halofantrine
- Mefloquine (Lariam®)
- Certain statin medications, such as:
- Atorvastatin (Lipitor®) or combination medications that contain atorvastatin (Caduet®)
- Lovastatin (Altoprev®, Mevacor®) or combination medications that contain lovastatin (Advicor®)
- Simvastatin (Zocor®) or combination medications that contain simvastatin (Juvisync®, Simcor®, Vytorin®)
- Codeine
- Class I and Class III arrhythmia medications, such as:
- Amiodarone (Cordarone®, Pacerone®)
- Disopyramide (Norpace®, Norpace® CR)
- Flecainide (Tambocor™)
- Mexiletine
- Phenytoin (Phenytek®, Dilantin®)
- Procainamide
- Propafenone (Rythmol®, Rythmol® SR)
- Quinidine
- Sotalol (Betapace®, Betapace AF®, Sorine®)
- CYP 3A4 inducer medications, such as:
- Aminoglutethimide (Cytadren®)
- Bosentan (Tracleer®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Dexamethasone (Decadron®, Dexpak®, Maxidex®)
- Efavirenz (Sustiva®)
- Efavirenz, emtricitabine, and tenofovir (Atripla®)
- Etravirine (Intelence™)
- Fosphenytoin (Cerebyx®)
- Nafcillin
- Nevirapine (Viramune®)
- Oxcarbazepine (Trileptal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®, Phenytek®)
- Primidone (Mysoline®)
- Rifabutin (Mycobutin®)
- Rifampin (Rifadin®)
- Rifapentine (Priftin®)
- St. John's wort (Hypericum perforatum)
- CYP 3A4 inhibitor medications, such as:
- Amprenavir (Agenerase®)
- Atazanavir (Reyataz®)
- Clarithromycin (Biaxin®)
- Conivaptan (Vaprisol®)
- Darunavir (Prezista®)
- Delavirdine (Rescriptor®)
- Erythromycin
- Fosamprenavir (Lexiva®)
- Imatinib (Gleevec®)
- Indinavir (Crixivan®)
- Isoniazid
- Itraconazole (Sporanox®)
- Ketoconazole (Nizoral®)
- Lopinavir and ritonavir (Kaletra®)
- Miconazole
- Nefazodone (Serzone®)
- Nelfinavir (Viracept®)
- Nicardipine (Cardene®)
- Posaconazole (Noxafil®)
- Quinidine
- Ritonavir (Norvir®)
- Saquinavir (Fortovase®, Invirase®)
- Telithromycin (Ketek®)
- Voriconazole (VFEND®)
- Dapsone
- Digoxin (Lanoxin®)
- Neuromuscular-blocking medications, such as:
- Atracurium
- Cisatracurium (Nimbex®)
- Pancuronium
- Rocuronium (Zemuron®)
- Succinylcholine (Anectine®, Quelicin®)
- Vecuronium (Norcuron®)
- Phenothiazine medications, such as:
- Chlorpromazine (Thorazine®)
- Fluphenazine (Prolixin®)
- Perphenazine (Trilafon®)
- Prochlorperazine (Compazine®, Compro®)
- Thioridazine (Mellaril®)
- Trifluoperazine (Stelazine®)
- Theophylline (Uniphyl®, Theochron®, TheoCap®, Theo-24®, Elixophyllin®)
- Tramadol (Ultram®), tramadol ER (Ultram® ER, Ryzolt™), or products that contain tramadol (Ultracet®)
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD