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Precautions and Warnings With Propoxyphene Hydrochloride

Prior to starting pain treatment with propoxyphene hydrochloride, it is important to understand that this medication can have negative effects, such as causing low blood pressure, irregular breathing, and drowsiness. Other precautions and warnings with propoxyphene hydrochloride involve the dangers of overdosing on this drug and the risks of using it while pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
 
You should talk with your healthcare provider prior to taking propoxyphene hydrochloride (Darvon®) if you have:
 
  • Depression
  • Suicidal tendencies
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • A history of drug or alcohol dependence
  • A bowel obstruction (blockage)
  • Low blood pressure (hypotension)
  • Lung disease of any sort
  • A head injury or high intracranial pressure
  • Asthma
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
     
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
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Propoxyphene Hydrochloride Drug Information

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